| 摘要: |
| 卵巢癌是性激素依赖性肿瘤，促性腺激素释放激素（gonadotropin releasing hormone，GnRH）类似物除了通过下丘脑-垂体-性腺轴间接抑制卵巢癌细胞外，还通过癌细胞上GnRH受体介导，直接抑制癌细胞的增殖、诱导凋亡等。此外，运用GnRH类似物对细胞的靶效应，将其作为载体载上细胞毒性药物，可以提高细胞毒性药物的功效、降低毒副作用。因此GnRH类似物的内分泌治疗为晚期及复发性卵巢癌提供了一种有价值的治疗措施。 |
| 关键词: 促性腺激素释放激素类似物 卵巢肿瘤 治疗 |
| DOI：10.3724/SP.J.1008.2008.01102 |
| 投稿时间：2008-03-13修订日期：2008-05-19 |
| 基金项目: |
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| Application of GnRH analogues in treatment of ovarian cancer |
| WANG Dan, HUI Ning* |
| (Department of Gynecology and Obstetrics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Ovarian cancer is sex hormone-dependent.Gonadotropin releasing hormone (GnRH) analogues inhibit ovarian cancer not only through the hypothalamus-pituitary-gonadal axis, but also through directly inhibiting the proliferation and inducing the apoptosis via GnRH receptors on the ovarian carcinoma cells.In addition, GnRH analogues target GnRH receptors on the cancer cells and can serve as a carrier for cytotoxic agents, improving the efficiency of cytotoxic agents and lowering the side effect.In a word, treatment with GnRH analogues may be a valuable alternative for advanced and recurrent ovarian cancer. |
| Key words: gonadotropin releasing hormone analogues ovarian neoplasms treatment |
