| 摘要: |
| 目的：探讨趋化因子CXCL12及其受体CXCR4与涎腺腺样囊性癌嗜神经侵袭之间的关系。方法：涎腺腺样囊性癌病例标本41例,舌癌病例标本30例,腮腺多形性腺瘤病例标本20例,正常神经组织标本20例。所有标本均制成4 μm厚的切片。应用EnVision法检测CXCR4在腺样囊性癌肿瘤组织内的表达以及CXCL12在周围神经组织内的表达。结果：腺样囊性癌癌组织内CXCR4阳性表达率为63.41%,显著高于舌癌(36.67%)及多形性腺瘤(35%) (P<0.05)；周围神经组织内CXCL12高表达 (64.38%),在腺样囊性癌内的神经组织与舌癌内的神经组织及正常神经组织中CXCL12阳性率无显著差异。 结论：趋化因子受体CXCR4在腺样囊性癌中高表达,趋化因子CXCL12在周围神经组织内高表达,提示CXCL12/CXCR4可能在腺样囊性癌嗜神经侵袭中发挥重要作用。 |
| 关键词: 涎腺肿瘤 腺样囊性癌 趋化因子 受体 神经侵袭 |
| DOI：10.3724/SP.J.1008.2008.00639 |
| 投稿时间：2008-04-09修订日期：2008-05-13 |
| 基金项目:国家自然科学基金 (30672330). |
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| Expression of CXCL12 and CXCR4 in salivary adenoid cystic carcinoma and peripheral nerve tissues |
| MENG Zhi-bing1,2,XU Xiao-gang1*,ZHOU Zhong-hua1* |
| (1.Department of Stomatology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;2.Department of Stomatology,The First People’s Hospital of Yangzhou,Yangzhou 225001) |
| Abstract: |
| Objective:To study the relationship between CXCL12/CXCR4 expression and the neural invasion of salivary adenoid cystic carcinoma (SACC).Methods: Totally 41 SACC specimens,30 tongue cancer specimens,20 pleomorphic adenoma specimens and 20 normal nerve specimens were included in the present study.The specimens were made into sections of 4 μm and EnVision method was used to detect the expression of the chemokine receptor CXCR4 in SACC sections and the expression of the chemokine CXCL12 in the peripheral nerve tissue sections.Results: The chemokine receptor was highly expressed in ACC cells.The positive rate of CXCR4 was 63.41% in the SACC sections,which was significantly higher than those in the tongue cancer group (36.67%) and the pleomorphic adenoma parotid group (35%) (P<0.05).The expression of CXCL12 was not significantly different between the nerve tissues of SACC,tongue cancer and the normal nerve tissues.Conclusion: The chemokine CXCL12 is elevated in the SACC cells and its receptor CXCR4 is elevated in the peripheral nerve tissues,indicating a role of the biological axis of CXCL12/CXCR4 in the neural invasion of salivary adenoid cystic carcinoma. |
| Key words: salivary gland neoplasms adenoid cystic carcinoma chemokines receptors neural invasion |
