| 摘要: |
| 树突状细胞(dendritic cell,DC)作为专职抗原递呈细胞,其强大的抗原递呈以及免疫调节能力越来越引起人们的重视。近年来认为,DC具有调控免疫应答的作用,不仅可激发免疫反应,也可介导免疫耐受。DC的这种异质性决定了DC在肿瘤、自身免疫性疾病及移植排斥的免疫反应中起着重要的作用。 |
| 关键词: 树突细胞 移植物排斥 免疫耐受 |
| DOI：10.3724/SP.J.1008.2008.01386 |
| 投稿时间：2008-05-07修订日期：2008-07-23 |
| 基金项目: |
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| Immune tolerance of dendritic cells and its role in graft rejection |
| ZOU Shao-wu1,FU Zhi-ren1,WANG Quan-xing2 |
| (1.Organ Transplantation Center, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;2.Department of Immunology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433) |
| Abstract: |
| As an antigen-presenting cell, dendritic cells (DCs)have drawn great attention due to its powerful antigen-presenting ability and immunological regulation function. Recently, it is believed that DCs also participate in regulation of immune response: DCs can not only stimulate immune response, but also induce immune tolerance. This heterogeneity of DCs determines that they play very important role in the immune response in tumors, autoimmunity diseases and graft rejections. |
| Key words: dendritic cells graft rejection immune response |
