| 摘要: |
| 目的:探讨血浆叶酸、同型半胱氨酸与胰腺癌的关系。方法:采用病例对照研究设计,以胰腺癌初诊患者为病例组,社区健康人群为对照组。采用酶联免疫吸附法测量研究对象血浆叶酸、同型半胱氨酸、维生素B12和维生素B6浓度,同时面对面调查其人口学特征、吸烟史、饮食习惯等因素。单因素分析分别采用χ2检验或t检验。选择单因素分析中P≤0.25的变量进行多因素Logistic回归分析。结果:共纳入胰腺癌病例42例,健康对照人群42例。单因素分析结果显示,两组血浆叶酸、同型半胱氨酸、维生素B12和维生素B6浓度虽无明显差别(P＞0.05),但这些因素均与胰腺癌潜在相关(P<0.25)。病例组蔬菜、水果、白肉和牛奶摄入量显著少于对照组(P<0.05)。多因素Logistic回归分析结果显示,叶酸、维生素B6和同型半胱氨酸的OR值(95%可信区间)分别为0.571(95%CI,0.383～0.851)、0.750(95%CI,0.557～1.011)和1.514(95%CI,0.986～2.326)。结论:血浆叶酸浓度增高可以降低胰腺癌发病风险,维生素B6可能是胰腺癌的保护因素,同型半胱氨酸可能是胰腺癌的危险因素。 |
| 关键词: 胰腺肿瘤 叶酸 同型半胱氨酸 病例对照研究 |
| DOI：10.3724/SP.J.1008.2009.0420 |
| 投稿时间：2008-07-15修订日期：2008-11-23 |
| 基金项目: |
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| Relationship of folic acid, homcysteine with pancreatic cancer: a case-control study |
| GUO Ai-zhen, CAI Quan-cai, CHEN Yan, ZHU Wei, LI Shu-de, LI Zhao-shen* |
| (Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Objective:To study the relationship of folic acid, homocysteine with pancreatic cancer. Methods: A case-control study was performed in which the case group was defined as patients with newly diagnosed pancreatic cancer and the control group were population-based healthy individuals. ELISA assay was used to determine the plasma levels of folic acid, homocysteine, vitamine B6 and vitamine B12 in all the subjects. The general information (such as demology data, smoking history, diet, etc) was collected by face to face talking using a standard questionnaire. Univariate analyses were performed using Chi-square tests for norminal variables and unpair t-tests for continuous variables. The variables with a P value no more than 0.25 in univariate analyses were selected as candidate variables for a multivariate logistic regression analysis. Results: Forty-two patients with pancreatic cancer and 42 healthy individuals were included in the present study. The results of univariate analyses showed that the plasma folic acid, homocysteine, vitamine B12 and vitamine B6 were not significantly different between the two groups (P＞0.05); they were potentially associated with pancreatic cancer (P<0.25), but were not significant risk factors(P＞0.05).The consumptions of vegetables, fruits, white meat and milk in case group was significantly less in the pancreatic cancer group than in the control group (P<0.05). Multivariate analysis showed that the odds ratios (95% CI) of plasma folic acid, vitamin B6, and homocysteine for pancreatic cancer were 0.571 (0.383-0.851), 0.750 (0.557-1.011), and 1.514 (0.986-2.326), respectively. Conclusion: Increased plasma folic acid can decrease the risk of pancreatic cancer. Plasma vitamin B6 might be a protective factor and homocysteine might be a risk factor of pancreatic cancer. |
| Key words: pancreatic neoplasms folic acid homocysteine case-control study |
