| 摘要: |
| 超微超顺磁性氧化铁(USPIO)作为磁共振对比剂具有血浆半衰期长、能够特异性结合巨噬细胞两个重要特性。相对于目前临床普遍使用的钆螯合物对比剂,USPIO对部分中枢神经系统疾病的诊断具有一些独特的优势,但仍有待进一步的临床研究确证。本文就近年来USPIO在部分中枢神经系统疾病磁共振影像诊断中的应用研究进展作一综述。 |
| 关键词: 超微超顺磁性氧化铁 巨噬细胞 动脉硬化斑块 多发硬化症 脑肿瘤 磁共振成像 |
| DOI：10.3724/SP.J.1008.2008.01503 |
| 投稿时间：2008-07-18修订日期：2008-09-22 |
| 基金项目: |
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| Application of ultrasmall superparamagnetic iron oxide in MRI diagnosis of central nervous system:recent progress |
| MA Xiao-long,LU Jian-ping* |
| (Department of Radiology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Ultrasmall superparamagnetic iron oxide (USPIO),as the contrast agent of MRI,possesses two major properties:long half time in the plasma and specific binding with macrophages.Compared with gadolinium,widely-used in clinic presently,USPIO has its unique advantages in diagnosis of central nervous system diseases,though which still need further clinical verification.This article reviews the application of USPIO in MRI diagnosis of some central nervous system diseases. |
| Key words: ultrasmall superparamagnetic iron macrophage atherosclerotic plaque multiple sclerosis brain neoplasms magnetic resonance imaging |
