| 摘要: |
| 水甘油通道3（AQP3）是一种即可以运输水分子又可以运输甘油等小分子物质的双功能水通道。皮肤角质细胞AQP3介导的甘油运输对于皮肤功能具有十分重要的意义,它的功能缺陷可导致皮肤干燥、弹性下降和屏障作用减弱等皮肤损伤,而过表达则增加了皮肤癌的危险。AQP3在皮肤功能方面的多重作用使其成为皮肤相关疾病治疗和护肤产品开发等的潜在靶点。本文就AQP3的特征、功能、应用及研究展望进行综述。 |
| 关键词: 水甘油通道3 甘油运输 水化作用 皮肤 |
| DOI：10.3724/SP.J.1008.2009.01416 |
| 投稿时间：2008-09-19修订日期：2009-06-27 |
| 基金项目: |
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| Aquaglyceroporin3-mediated glycerol transport and skin function |
| GUO Xiao-qiang |
| (Department of Biochemistry,Bethune Military Medical College,Shijiazhuang 050081,China) |
| Abstract: |
| Aquaglyceroporin3 (AQP3),a dual function water channel,can transport both water molecule and other small molecular substances such as glycerol.AQP3-mediated glycerol transport in skin is very important for skin function,whose absence can lead to dry skin,decreased elasticity,and impaired barrier function,and whose overexpression is related to higher risk of skin tumorigenesis.The multiple roles of AQP3 in skin function make it a potential target in treatment of skin disease and development of cosmetics.This paper reviews the characteristics,function,application,and research perspective of AQP3. |
| Key words: AQP3 glycerol transport hydration skin |
