| 摘要: |
| 侧群细胞(SP)是一类具有干细胞特性,能够排出活性染料Hoechst33342具有弱荧光染色特性的细胞。利用此特性SP细胞可以通过流式细胞仪被分选;其排出染料的能力与其细胞膜上的ATP结合盒转运子有关。目前已经在许多组织、器官中分离出SP细胞,且不同来源的SP细胞具有某些共性。本文就甲状腺SP细胞的分类、表面标志物以及相关特征作一综述。 |
| 关键词: 甲状腺 SP细胞 干细胞 |
| DOI：10.3724/SP.J.1008.2009.0840 |
| 投稿时间：2008-10-17修订日期：2009-03-31 |
| 基金项目: |
|
| Side population cells of thyroid gland:research progress |
| GE Hui-juan,YANG Xiao-qun,YU Hong-yu* |
| (Department of Pathology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China) |
| Abstract: |
| Side population (SP) cells are highly enriched for stem cell activity and characterized by their ability to efflux the vital dye Hoechst 33342,because they express the ATP binding cassette (ABC)-dependent transporter ABCG2.SP cells can be selected from main population using flow cytometric analysis.Currently SP cells have been isolated from many tissues and organs.SP cells of different origins have some common characteristics.This article introduces the classifications,surface marker,and characteristics of SP cells. |
| Key words: thyroid gland SP cell stem cell |
