| 摘要: |
| 肥胖是大肠癌的危险因素之一,其机制迄今未明。脂联素作为脂肪组织分泌的一种蛋白质,可能在肥胖与大肠癌发病关系中起重要作用。本文从脂联素的分子特征、与大肠癌的关系以及可能的抗肿瘤机制等方面对该领域的研究进展情况进行了综述。 |
| 关键词: 脂联素 脂联素受体；结直肠肿瘤 |
| DOI：10.3724/SP.J.1008.2009.01308 |
| 投稿时间：2008-11-18修订日期：2009-09-14 |
| 基金项目: |
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| Adiponectin and colorectal cancer: an update |
| AN Wei,CAI Quan-cai,LI Zhao-shen* |
| (Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Obesity is a risk factor for colorectal cancer,but the underlying mechanism remains unclear. Adiponectin as an adipocyte-derived protein might play an important role between obesity and colorectal cancer. Here we review the current progress on molecular characteristics of adiponectin,the association of adiponectin with colorectal cancer,and the possible anti-tumor mechanism. |
| Key words: adiponectin adiponectin receptors colorectal neoplasms |
