| 摘要: |
| 立方晶是两亲性脂质和表面活性剂在水中自发形成的立方液晶的纳米分散体系。立方晶属于自稳定体系,是双连续的水相和脂相形成的类似“蜂窝”状的结构,在其中表面活性剂插入脂质双分子层,晶胞在三维方向上以无限循环方式排列,形成极小曲面的紧密结构。立方晶独特的脂水双连续相立方液晶结构,能够同时增溶亲水、亲脂及两亲性分子,具有生物可降解性、高生物黏附性、制备工艺简单等诸多优点使之在药物载体领域展现较大的优势。本文结合近年文献报道,阐述了立方晶的结构、制备、表征和药物载体的研究进展。 |
| 关键词: 立方晶 立方液晶 纳米粒 单油酸甘油酯 结构 制备 表征 药物载体 |
| DOI：10.3724/SP.J.1008.2009.0834 |
| 投稿时间：2008-12-04修订日期：2009-06-01 |
| 基金项目: |
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| Cubosomes as drug delivery system: recent advance |
| CHEN Yan,CHEN Jian-ming,CHEN Ming,GAO Shen,ZHONG Yan-qiang* |
| (Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Cubosomes are self-assembled nanostructured particles formed by aqueous lipid and surfactant systems.Cubosomes are thermodynamically stable; they have a structure like “honeycombed” with bicontinuous domains of water and lipid in which surfactant assembles into bilayers and twisted into a three dimension,periodic,and minimal surface,forming a tightly packed structure.The properties of cubosomes,such as its unique bicontinuous cubic phase liquid crystals,its ability to solubilize hydrophobic,hydrophilic,and amphiphilic molecules at the same time,its biodegradability by simple enzyme action,its strong bioadhesion ability,and its simple preparation,make them a promising vehicle for drug delivery.Based on recent reports,this review introduces the structure,preparation,exosyndrome and drug delivery potential of cubosomes. |
| Key words: cubosomes cubic liquid crystalline phase nanoparticles monoolein structure preparation exosyndrome drug delivery |
