| 摘要: |
| 目的:研究鸦胆子油自乳化制剂，探求其最佳处方配比，进行剂型改进。方法:通过溶解度实验、正交筛选和伪三元相图的绘制，以乳化程度、未乳化油的体积和所得乳滴粒径的大小为指标，对鸦胆子油处方中的药物、油相、表面活性剂的用量比例进行筛选，寻找出最佳的搭配和处方配比。结果:在鸦胆子油的自乳化制剂处方中，当油相选用中链脂肪酸三酰甘油、非离子表面活性剂选用吐温-85时，可以获得较好的乳化效果，粒径为0.169 2 μm，且乳化制剂的质量、稳定性与重现性良好。结论:鸦胆子油自乳化的最佳处方比例为鸦胆子油中链脂肪酸三酰甘油吐温-85=114。 |
| 关键词: 鸦胆子油 自乳化 剂型改进 |
| DOI：10.3724/SP.J.1008.2009.01069 |
| 投稿时间：2008-12-15修订日期：2009-07-30 |
| 基金项目: |
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| Recipe for self-emulsifying preparation of Brucea javanica seed oil |
| LIU Yan1,LI Guo-dong2*,LIU Cheng-chu1 |
| (1.Department of Ocean Drug Development,College of Food Industry,Shanghai Ocean University,Shanghai 201306,China; 2.Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433) |
| Abstract: |
| Objective:To search for the optimum formula for self-emulsifying preparation of Brucea javanica seed oil.Methods: Taking the emulsifying degree,quantity of non-emulsifying oil,and emulsion particle size as parameters,we screened for the optimum proportions of the oil,lipids, and non-ionic surfactant in the recipe formulation through solubility experiment,orthogonal screen and drawing pseudo-three-phase diagram.Results: For the formulation of Brucea javanica seed oil,better emulsifying effect could be obtained using medium chain length fatty acid triglyceride as the lipids and Tween-85 as the non-ionic surfactant,with the emulsion particle diameter being 0.169 2 μm.And the self-emulsifying preparation had satisfactory quality,stability, and reproducibility.Conclusion: The optimum formula for self-emulsification of Brucea javanica seed oil is:Brucea javanica seed oil∶medium chain triglycerides∶Tween-85 being 1∶1∶4. |
| Key words: brucea javanica seed oil self-emulsifying dosage form improving |
