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COX-2、u-PA和TSP-1在胃癌及周围淋巴结中的表达及意义
张富花1,2,周永宁1*,张锦华2,庄剑波2,李强1,李高中1,陆斌1,张志镒3,吴正奇3
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(1.兰州大学第一医院消化科,兰州 730000;2.甘肃省第二人民医院消化科,兰州 730000;3.甘肃省武威肿瘤医院消化科,武威 733000)

摘要:

目的:研究COX2、uPA和TSP1在胃癌及周围淋巴结中的表达状况,探讨它们在胃癌浸润和淋巴结转移中的作用和意义。方法:用组织芯片技术和免疫组化法检测COX2、uPA和TSP1的表达。结果:COX2、uPA和TSP1在胃癌组阳性表达率分别为67.7%、78.1%和78.6%,均显著高于对照组（40.0%、6.7%和40.0%,P＜0.05）。COX2表达与浸润深度有关（P＜0.05）。uPA表达与浸润深度和淋巴结转移均有关（P＜0.05）。TSP1表达与浸润深度和淋巴结转移均无关（P>0.05）。COX2、uPA和TSP1在转移淋巴结和对应癌组织间的表达差异无显著性（P>0.05）。COX2和uPA、TSP1的表达呈正相关,uPA和TSP1的表达无相关关系。结论:胃癌中COX2、uPA和TSP1高表达； COX2表达与胃癌的浸润深度有关,uPA表达与浸润深度和淋巴结转移有关。

关键词: 胃肿瘤 COX 2 u PA TSP 1 淋巴结肿瘤浸润淋巴转移

DOI：DOI:10.3724/SP.J.1008.2009.00771

投稿时间：2008-12-20修订日期：2009-05-05

基金项目:国家自然科学基金（30872478C160401）.

Expression of cyclooxygenase-2,urokinase plasminogen activator and thrombospondin 1 in gastric carcinoma and surrounding peripheral lymph nodes

ZHANG Fu-hua1,2,ZHOU Yong-ning1* ,ZHANG Jin-hua2,ZHUANG Jianbo2 ,LI Qiang1,LI Gao-zhong1,LU Bin1,ZHANG Zhi-yi3,WU Zheng-qi3

(1.Department of Gastroenterology,the First Hospital of Lanzhou University,Lanzhou 730000,China;2.Department of Gastroenterology,the Second People’s Hospital of Gansu Province,Lanzhou 730000; 3.Department of Gastroenterology,Cancer Hospital of Gansu Province,Wuwei 733000)

Abstract:

Objective:To investigate the expression of cyclooxygenase2 (COX2),urokinase plasminogen activator(uPA),and thrombospondin1 (TSP1) in gastric carcinoma and the surrounding lymph nodes,so as to discuss their roles in the invasion and metastasis of gastric carcinoma.Methods:The expression of COX2,uPA,and TSP1 in the samples was examined by tissue microarray and SP immunohistochemistry staining.Results:The positive rates of COX2,uPA,and TSP1 in gastric carcinoma were 67.7%,78.1%,and 78.6%,respectively,which were significantly higher than those in the surrounding lymph nodes(40.0%,6.7%, and 40.0%,respectively,P＜0.05).The expression of COX2 was significantly correlated with the depth of invasion (P＜0.05）.The expression of uPA was significantly correlated with lymph node metastasis and depth of invasion (P＜0.05).The expression of TSP1 was neither correlated with lymph node metastasis nor depth of invasion (P>0.05).COX2,uPA,and TSP1 expression was not significantly different between metastatic lymph nodes and corresponding gastric carcinoma.COX2 expression was positively correlated with uPA,and TSP1 expression.TSP1 expression was not correlated with uPA expression.Conclusion:COX2,uPA,and TSP1 are highly expressed in the gastric carcinoma.COX2 expression is correlated with depth of invasion.UPA expression is significantly related with depth of invasion and lymph node metastasis.

Key words: stomach neoplasms COX 2 u PA TSP 1 lymph node neoplasm invasiveness lymphatic metastasis