| 摘要: |
| 髓样细胞表达的激发受体-1(triggering receptors expressed by myeloid cells-1,TREM-1)是新近发现的参与单核细胞作用和炎症反应的分子,是自然杀伤细胞受体家族成员,表达于中性粒细胞、成熟单核细胞及巨噬细胞,能增强由Toll样受体(TLR)-2和-4启动的炎症反应,扩大急、慢炎症反应。细菌或真菌感染患者体液中可检测到可溶性TREM-1(sTREM-1),提示其可作为感染的诊断指标；针对TREM-1的靶标治疗是值得深入探讨的抗炎治疗新方法。本文就炎症相关疾病中TREM-1的研究进展作一综述。 |
| 关键词: 髓样细胞表达的激发受体-1 炎症 肿瘤 诊断 治疗 |
| DOI：10.3724/SP.J.1008.2009.01206 |
| 投稿时间：2009-02-03修订日期：2009-06-25 |
| 基金项目:国家自然科学基金面上项目(30772138). |
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| Triggering receptor expressed on myeloid cells-1 and inflammation-associated diseases: recent progress |
| XU Ai-ping,LU Zheng,LI Shu-de,LI Zhao-shen* |
| (Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Triggering receptor expressed on myeloid cells-1(TREM)-1,a recently identified molecule,is involved in monocytic activation and inflammatory responses.TREM-1 is a member of natural killer cell receptor family and is expressed on neutrophils,mature monocytes and macrophages,and it can enhance the inflammatory responses mediated by Toll-like receptor-2 and -4,showing a role of inflammation promotion.Reportedly sTREM-1 was detectable in the body fluids in the presence of bacterial or fungal infection; therefore it might be used as a marker for inflammation.In addition,recombinant sTREM-1 may also be a new method for anti-inflammatory therapy.Recently,it has been found that TREM-1 not only promoted the acute inflammatory responses,but also participated in the development of chronic inflammation.This review summarizes the role of TREM-1 in the inflammation-associated dieases. |
| Key words: triggering receptor expressed on myeloid cells-1 inflammation neoplasms diagnosis therapy |
