| 摘要: |
| 胰岛B细胞数量减少及分泌胰岛素能力下降是2型糖尿病发病的主要机制之一。新近的研究显示,自噬在保护胰岛B细胞以及维持胰岛B细胞结构、数量、分泌能力、内环境的稳定等方面有重要的作用。自噬已是近年来的研究热点,在肿瘤、神经、衰老等领域研究广泛,但在胰岛B细胞方面的研究起步较晚,相关报道也较少。本文就自噬的概念及自噬在维持胰岛B细胞正常功能方面的作用等作一综述。 |
| 关键词: 自噬 胰岛B细胞 2型糖尿病 |
| DOI：10.3724/SP.J.1008.2009.01413 |
| 投稿时间：2009-04-17修订日期：2009-06-22 |
| 基金项目: |
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| The role of autophagy in maintaining pancreatic beta-cell function |
| WU Jie,ZOU Da-jin* |
| (Department of Endocrinology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Disrupted pancreatic β-cell function and decreased β-cell number are two of the main causes of type 2 diabetes mellitus.Recent studies have indicated that autophagy plays an important role in protecting pancreatic β-cell and in maintaining the structure,number,and secretive function of pancreatic β-cell.Although autophagy has been a focus of study in recent years, including areas such as tumor,neural diseases and aging,but its relationship with pancreatic β-cell was not included.In this paper we review the concept of autophagy and its role in maintaining the normal function of pancreatic β-cells. |
| Key words: autophagy pancreatic beta-cell type 2 diabetes |
