| 摘要: |
| 目的:考察水飞蓟宾磷脂复合物在大鼠全小肠段及各分肠段的吸收。方法:运用大鼠在体肠灌流实验，采用高效液相色谱法测定肠灌流液中药物和酚红的浓度，以吸收百分率和肠壁通透系数为指标，考察水飞蓟宾磷脂复合物的肠吸收特性和肠壁通透性。结果:水飞蓟宾磷脂复合物在小肠中的吸收呈一级动力学特征，6 h时在肠道中约有70％被吸收，吸收速率常数Ka值为(0.193±0.012) h-1；分肠段实验中，各肠段（十二指肠、空肠、回肠、结肠）的吸收百分率和肠壁通透系数均无显著性差异（P>0.05）。结论: 水飞蓟宾磷脂复合物在全肠道均有吸收。 |
| 关键词: 水飞蓟宾 磷脂复合物 肠吸收 在体肠灌流 |
| DOI：10.3724/SP.J.1008.2009.01288 |
| 投稿时间：2009-06-15修订日期：2009-09-27 |
| 基金项目: |
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| Absorption characteristics of silybin-phospholipid complex by rat intestine |
| YANG Qiu-xia1,MA Fu-jia2,ZHANG Lan-lan3,CHEN Jian-ming1* |
| (1.Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;2.Department of Pharmacy,No.455 Hospital of PLA,Shanghai 200052;3.Modern TCM Institute,Tasly Pharmaceutical Co.,Ltd,Tianjin 300402) |
| Abstract: |
| Objective:To investigate the intestinal absorption of silybin-phospholipid complex by the whole and different segments of rat’s intestine.Methods: An in situ intestinal perfusion model was employed in the present research; and absorption percent and intestinal wall permeability coefficient (Ke) were taken as indices.HPLC method was used to determine the concentrations of silybin and phenol red in the perfusate to calculate the absorption indices.Results: The absorption of silybin-phospholipid complex was a first-order process,about 70% of it was absorbed after 6 h,with the absorption rate constants(Ka) being (0.193±0.012) h-1.The absorption rate and Ke for silybin-phospholipid complex were similar between different intestinal segments (Duodenum,Jejunum,Ileum,and Colon) （P>0.05）.Conclusion: Silybin-phospholipid complex can be absorbed in the whole intestinal segments. |
| Key words: silybin phospholipid complex intestinal absorption in situ intestine perfusion |
