| 摘要: |
| 内源性硫化氢(H2S)是继一氧化氮(NO)和一氧化碳(CO)之后发现的第3种气体信号分子,通过胱硫醚-β-合成酶(CBS)和胱硫醚-γ-裂解酶 (CSE)途径合成或产生。它通过直接作用于KATP通道、减少细胞外Ca2+的内流及与睾酮、NO、CO协同作用等方式来舒张阴茎海绵体血管平滑肌,改善血管舒张功能；还可抑制血管平滑肌细胞增殖,促进其凋亡,改善血管重构。因此,深入研究H2S在阴茎勃起调节中的作用,可为治疗勃起功能障碍(ED)提供新的途径。 |
| 关键词: 硫化氢 胱硫醚-β-合酶 胱硫醚-γ-裂合酶 阴茎勃起 勃起功能障碍 |
| DOI：10.3724/SP.J.1008.2010.0207 |
| 投稿时间：2009-08-06修订日期：2009-11-24 |
| 基金项目: |
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| Gaseous signal molecule hydrogen sulfide and penile erection |
| LUO Hua, FENG Ai-ping, QIU Ming-quan |
| (Department of Urology, the Second People’s Hospital of Deyang, Deyang 618000, Sichuan, China) |
| Abstract: |
| Endogenous hydrogen sulfide is the third gaseous signal molecule after nitric oxide and carbon monoxide; it is synthesized through cystathionine-β-synthase and cystathionine-γ-cleavage pathway.Hydrogen sulfide can directly react with the KATP channel, reduce extracellular Ca2+ influx, and work together with testosterone, nitric oxide, carbon monoxide, relaxing corpus cavernosum smooth muscle and improving diastolic function of blood vessels.It can also inhibit vascular smooth muscle cell proliferation, promote apoptosis, and improve vascular remodeling.Therefore, in-depth study of H2S in the regulating penile erection can provide a new way for the treatment of erectile dysfunction. |
| Key words: hydrogen sulfide cystathionine-beta-synthase cystathionine-γ-lyase penile erectile erectile dysfunction |
