| 摘要: |
| 生长分化因子-15(growth differentiation factor-15, GDF-15)是转化生长因子β(transforming growth factor β,TGF-β)超家族成员的一个远支,是一个重要的心血管保护因子。作为新的标志物, GDF-15水平与多种心血管疾病的诊断、危险分层和预后判断有密切关系。本文就GDF-15基因的生物学特点及其在心血管疾病中的多种功能作一综述。 |
| 关键词: 生长分化因子15 转化生长因子β 心血管疾病 |
| DOI：10.3724/SP.J.1008.2010.0317 |
| 投稿时间：2009-08-12修订日期：2009-11-19 |
| 基金项目: |
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| Growth differentiation factor-15 in cardiovascular disease: from bench to bedside |
| GU Yu-ying, ZHANG Dai-fu* |
| (Department of Cardiology, East Hospital, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Growth differentiation factor (GDF)-15, a distant member of the transforming growth factor-β cytokine superfamily, is a powerful cardioprotective factor. Many studies have demonstrated that serum GDF-15 level is a novel marker closely associated with the diagnosis, risk stratification, and prognosis of several cardiovascular diseases. This article mainly reviews the characteristics of GDF-15 and its multifunction in cardiovascular diseases. |
| Key words: growth differentiation factor-15 transforming growth factor-β cardiovascular diseases |
