| 摘要: |
| 严重烧伤、创伤后可引起胰岛素抵抗(insulin resistance,IR)。IR导致代谢紊乱,血糖异常升高,对常规剂量胰岛素治疗效果不显著。长期大剂量的胰岛素治疗,有时会出现低血糖,危及患者生命安全,使病情变得复杂,不利于临床治疗。目前,IR的发生机制尚未完全明确,本文对严重烧伤后IR的受体后信号转导机制及其影响因素的研究作一综述。 |
| 关键词: 烧伤 胰岛素抵抗 受体后信号转导 胰岛素受体 |
| DOI：10.3724/SP.J.1008.2011.088 |
| 投稿时间：2010-06-20修订日期：2010-12-03 |
| 基金项目:国家自然科学基金(30872684). |
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| Insulin resistance and deficiency of post-receptor signal transduction after severe burns |
| PAN Bo-han,CHANG Fei,LU Wei* |
| (Department of Burns, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Severe burns and trauma can lead to insulin resistance (IR), which is associated with the metabolic disorder and hyperglycemia, and routine insulin treatment yield no noticeable outcome. However, long time bigdose insulin treatment can sometimes cause hypoglycemia, threatening the life of patients and making the condition more complicated to treat. By now, the mechanism of IR is not yet clearly understood. This article reviews the recent researches about the postreceptor signal transduction mechanism of IR after severe burns and its influencing factors. |
| Key words: burns insulin resistance post-receptor signal transduction insulin receptor |
