| 摘要: |
| 原发性肝细胞癌是全球第5位常见恶性肿瘤, 也是近年来发病率上升最快的肿瘤之一, 其病死率位于因癌症而死亡的第3位。引起肝癌的危险因素很多, 我国主要是由乙型肝炎病毒感染引起, 其中有25%~30%的乙型肝炎患者可发展为肝硬化进而演变为肝癌。人们针对肝癌的危险因素进行了大量的流行病学研究, 发现代谢综合征与肝癌有密切相关性, 甚至可以成为独立的危险因素影响肝癌的发生、发展。非酒精性脂肪性肝病(NAFLD)是代谢综合征在肝脏的临床表现, 最近大量文献报道NAFLD作为最常见的肝脏疾病之一与肝癌的发生有密切联系。本文就代谢综合征及肝癌相关性的研究进行了复习, 为了解两者之间的关系提供参考。 |
| 关键词: 肝肿瘤 代谢综合征 肥胖 胰岛素抵抗 非酒精性脂肪性肝病 隐源性肝硬化 |
| DOI：10.3724/SP.J.1008.2010.0425 |
| 投稿时间：2009-08-26修订日期：2010-03-09 |
| 基金项目:国家自然科学基金（30971345）, 上海市优秀学科带头人计划（09XD1405800）. |
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| Metabolic syndrome and hepatocellular carcinoma: an advance in epidemiology study |
| ZHAO Jin-yan, GAO Chun-fang* |
| (Department of Laboratory Diagnosis, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China) |
| Abstract: |
| Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related death worldwide; meanwhile, it is also one of the fastest growing malignancies. The causes of HCC are multiple; HBV is the most important cause in China, with about 25%-30% of HBV infection patients finally develop hepatic cirrhosis and liver cancer. At present, large scale epidemiological studies revealed that the metabolic syndrome (MS) was closely related to liver cancer, and it even served as an independent risk factor for the occurrence and progression of liver cancer.Non-alcoholic fatty liver disease is a metabolic syndrome clinically manifested in the liver; recently it has been indicated to be closely related with HCC development and progression. This paper reviews the recent researches on metabolic syndrome and liver cancer, so as to provide literature for preventive and therapeutic studies on non-virus-related liver cancer. |
| Key words: liver neoplasms metabolic syndrome obesity insulin resistance non-alcoholic fatty liver disease cryptogenic cirrhosis |
