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| 肥胖性高血压机制研究进展 |
| 罗益滨1△,朱天怡2△,陈震3,武晋晓1*,彭晓君4 |
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| (1.北京军区总医院内分泌科,北京 100700;2.第二军医大学研究生院,上海 200433;3.北京军区总医院医务部,北京 100700;4.北京军区总医院内科学教研室,北京 100700) |
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| 摘要: |
| 肥胖是原发性高血压的第一危险因素。肥胖性高血压发病率与日俱增,已经成为一个不容忽视的全球性问题,但其机制尚未完全阐明。本文复习了近年来的相关文献,着重从低血清脂联素、瘦素及瘦素抵抗、胰岛素及胰岛素抵抗、肾素血管紧张素系统激活4个方面阐述了肥胖性高血压的发生、发展机制。 |
| 关键词: 肥胖性高血压 脂联素 瘦素 胰岛素 肾素 血管紧张素系统 |
| DOI：10.3724/SP.J.1008.2010.0442 |
| 投稿时间：2009-10-04修订日期：2010-01-28 |
| 基金项目: |
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| Mechanisms of obesity related hypertension:recent progress |
| LUO Yi-bin1△, ZHU Tian-yi2△, CHEN Zhen3, WU Jin-xiao1*, PENG Xiao-jun4 |
| (1. Department of Endocrinology, General Hospital, PLA Beijing Military Area Command, Beijing 100700, China;2. Postgraduate College, Second Military Medical University, Shanghai 200433, China;3. Medical Department, General Hospital, PLA Beijing Military Area Command, Beijing 100700, China;4. Department of Internal Medicine, General Hospital, PLA Beijing Military Area Command, Beijing 100700, China) |
| Abstract: |
| Obesity is the most important risk factor of primary hypertension.Rapid increase of obesityrelated hypertension has become a worldwide problem. But the specific mechanism of the condition remains to be fully understood. This paper reviews the latest literatures and tries to explain the mechanism of obesityrelated hypertension from the following four aspects:hypoadiponectinemia, leptin and resistance of leptin, insulin and resistance of insulin and the activation of reninangiotensin system(RAS). |
| Key words: obesity related hypertension adiponectin leptin insulin renin angiotensin system |
