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| 肿柄菊乙酸乙酯部位的化学成分 |
| 赵贵钧1,3,张崇禧2,吴志军1,李霞1,杨颖博1,孙连娜1*,郑水庆1 |
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| (1.第二军医大学药学院生药学教研室,上海 200433;2.山东大学威海分校海洋学院,威海 264209;3.吉林农业大学中药材学院,长春 130118) |
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| 摘要: |
| 目的肿柄菊乙酸乙酯部位化学成分的提取、分离和结构鉴定。方法肿柄菊地上部分80%的乙醇渗漉提取,通过萃取、硅胶柱层析、凝胶柱层析、MCI柱层析等方法进行成分分离,应用质谱、核磁等方法进行结构鉴定。结果从乙酸乙酯部位得到10个化合物,鉴定为香草醛(1)、麦角甾醇(2)、过氧化麦角甾醇(3)、 3-甲氧基-4-羟基肉桂醛(4)、对羟基苯甲醛(5)、异东莨菪内酯(6)、5-羟甲基糠醛(7)、尼泊尔黄酮(8)、二十二烷酸单甘油酯(9)和 13-羟基泽兰烯(10)。结论香草醛、麦角甾醇、过氧化麦角甾醇、3-甲氧基-4-羟基肉桂醛、对羟基苯甲醛、异东莨菪内酯、5-羟甲基糠醛、二十二烷酸单甘油酯和13-羟基泽兰烯均为首次从肿柄菊中分离得到。 |
| 关键词: 肿柄菊 化学成分 乙酸乙酯部位 |
| DOI：10.3724/SP.J.1008.2010.0189 |
| 投稿时间：2009-10-15修订日期：2009-12-03 |
| 基金项目:国家自然科学基金(20872177),上海市科委中药现代化专项资助项目(08DZ1971503). |
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| Chemical constituent analysis of EtOAc fraction of Tithonia diversifolia(HEMSL.) A.Gray |
| ZHAO Gui-jun1,3, ZHANG Chong-xi2, WU Zhi-jun1, LI Xia1, YANG Ying-bo1, SUN Lian-na1* , ZHENG Shui-qing1 |
| (1.Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;2.Marine College, Weihai Branch of Shandong University, Weihai 264209, Shandong, China;3.College of Chinese Herbal Medicine, Jilin Agricultural University, Changchun 130118, Jilin, China) |
| Abstract: |
| ObjectiveTo isolate and identify the chemical constituents of the EtOAc fraction of Tithonia diversifolia.MethodsThe dried aerial parts of Tithonia diversifolia were extracted with 80% EtOH,and the chemical constituents of the ethyl acetate portion from the extract were isolated by column chromatography with silica gel, Sephadex LH-20 and MCI.The isolated compounds were identified by NMR and MS analysis.ResultsTen compounds were isolated from EtOAc extract, and identified as:vanillin(1), ergosterol(2), ergosterol peroxide(3), 3-methoxy-4-hydroxy-trans-cinnamaldehyde(4), p-hydroxybenzaldehyde(5), 7-methylesculetin(6), 5-hydyoxymethyl furfural(7), nepetin(8), docosanoic acid 2, 3-dihydroxypropyl ester(9) and 13-hydroxyeupatorochromene(10).ConclusionVanillin, ergosterol, ergosterol peroxide, 3-methoxy-4-hydroxy-trans-cinnamaldehyde, p-hydroxybenzaldehyde, 7-methylesculetin, 5-hydyoxymethyl furfural, docosanoic acid 2, 3-dihydroxypropyl ester, and 13-hydroxyeupatorochromene have been isolated from Tithonia diversifolia for the first time. |
| Key words: Tithonia diversifolia chemical constituents ethyl acetate portion |
