| 摘要: |
| \[摘要\] 由α1,6岩藻糖基转移酶(α1,6fucosyltransferase,Fut8)催化的核心岩藻糖基化是糖蛋白重要的翻译后修饰和功能调控方式,直接影响细胞一系列生物学特性,而这种糖基化的异常改变往往是疾病状态的特点。本文就Fut8的表达调控特征、生物学功能及其与各种肿瘤的关系研究进展作一综述。 |
| 关键词: α 1,6岩藻糖基转移酶 基因 肿瘤 |
| DOI：10.3724/SP.J.1008.2011.0209 |
| 投稿时间：2009-11-02修订日期：2010-12-09 |
| 基金项目:国家自然科学基金（30971345）,上海市优秀学科带头人计划（09XD1405800）. |
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| α1, 6 fucosyltransferase and tumor: recent progress |
| JI Jun, GAO Chun-fang* |
| (Department of Laboratory Diagnosis,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University, Shanghai 200438, China) |
| Abstract: |
| \[Abstract\] Core fucose glycosylation catalyzed by α1, 6fucosetransferase(Fut8) is an important way for protein posttranslational modification and functional regulation; it directly influences a series of biological characteristics of cells and is always seen under some pathological conditions. This paper reviews the recent studies on the regulation, biological function of Fut8 and its relationship with different kinds of tumors. |
| Key words: α1, 6 fucosyltransferase genes neoplasms |
