| 摘要: |
| 系统性红斑狼疮(systemic lupus erythematosus,SLE)的病因及发病机制至今尚未完全清楚,作为Th1型细胞因子之一的干扰素γ(IFN-γ)可能参与了SLE的发病及炎症过程。本文就近年来国内外对狼疮患者及狼疮鼠模型的血清、体外细胞培养分泌的IFN-γ水平、IFN-γ诱导蛋白和IFN-γ相关基因表达以及中医药治疗等方面的研究作一综述。 |
| 关键词: 干扰素γ Th1型细胞因子 系统性红斑狼疮 |
| DOI：10.3724/SP.J.1008.2010.00 |
| 投稿时间：2010-02-04修订日期：2010-04-12 |
| 基金项目:上海市教育委员会科研项目(07cz045). |
|
| Interferon-gamma and systemic lupus erythematosus |
| xiajia,suxiao |
| (shanghai municipal TCM hospital affiliated to shanghai TCM university) |
| Abstract: |
| The etiology and pathogenesis of systemic lupus erythematosus(SLE) remain unclear. Interferon-γ (IFN-γ),a Th1-type cytokine, may be involved in the pathogenesis and inflammatory process of SLE. This article reviews reports on the serum IFN-γ of SLE patients and mouse SLE models, in vitro secreted IFN-γ, expression of IFN-γ induced protein and IFN-γ related genes, and treatment with traditional Chinese medicines. |
| Key words: interferon-γ Th1-type cytokine systemic lupus erythematosus |
