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| 可显影碘化油-氟尿嘧啶聚乳酸微球的研制 |
| 王新霞1,张丽2,周闺臣3,张国庆1,鲁莹3,钟延强3*,钟延强3* |
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| (1.第二军医大学东方肝胆外科医院药材科,上海 200438;2.解放军71352部队医院药房,安阳 455000;3.第二军医大学药学院药剂学教研室,上海 200433) |
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| 摘要: |
| 目的制备用于肝动脉栓塞的可显影碘化油-氟尿嘧啶(iodized oil-5-fluorouracil,iodized oil-5-Fu)聚乳酸(polylactide acid, PLA)微球。方法选择具有良好生物相容性及生物可降解性的聚乳酸为载体,加入阳性造影剂碘化油,采用复乳法制备可显影碘化油-氟尿嘧啶聚乳酸微球。以外观、粒径、载药量、包封率为考察指标,采用正交设计确定可显影碘化油-氟尿嘧啶聚乳酸微球的制备工艺。结果显微镜下微球球形圆整,粒径分布均匀,扫描电镜下微球表面有孔,平均粒径约100 μm；载药量(10.78%±0.14%),包封率(63.34%±0.545%),微球显影效果好。结论以可生物降解的PLA材料可制备显影效果好的氟尿嘧啶微球,并且微球具有一定的缓释作用。 |
| 关键词: 氟尿嘧啶 聚乳酸 碘化油 微球体 复乳法 |
| DOI：10.3724/SP.J.1008.2010.01100 |
| 投稿时间：2010-03-12修订日期：2010-09-13 |
| 基金项目: |
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| Preparation of visualized iodized oil-5-fluorouracil loaded polylactic acid microspheres |
| WANG Xin-xia1, ZHANG Li2, ZHOU Gui-chen3, ZHANG Guo-qing1, LU Ying3, ZHONG Yan-qiang3*,ZHONG Yan-qiang3* |
| (1. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China;2. Department of Pharmacy, Hospital of No. 71325 Troop, Anyang 455000, Henan, China;3. Department of Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| ObjectiveTo prepare visualized iodized oil-5-fluorouracil loaded polylactic acid(PLA) micropheres for hepatic artery embolism treatment.MethodsBiocompatible and biodegradable material PLA was used as vector and iodized oil was used as positive contrast agent to prepare 5-fluorouracil loaded microspheres using double emulsion method. The preparation technology of the microspheres was developed through optimization of appearance, size distribution, drug loading, and encapsulation efficiency by orthogonal-designing method.ResultsThe prepared PLA microspheres were round in shape and had a homogenous diameter distribution. Scanning electron microscope (SEM) showed a pored surface, with an average diameter of 100 μm. The encapsulation efficiency and drug content of microspheres were (63.34%±0.54%) and (10.78%±0.14%), respectively.ConclusionWe have successfully prepared the visualized iodized oil-5-fluorouracil PLA microspheres, which can release 5-fluorouracil in a controlled manner. |
| Key words: fluorouracil polylactic acid iodized oil microspheres double emulsion method |
