| 摘要: |
| \[摘要\]近年来,随着研究的深入,一氧化氮(NO)越来越多的生物学功能逐渐被发现。以往国内外很多报道都证实NO在抗微生物感染方面起到重要作用,然而近年来的一些发现表明,NO对微生物的生长还起到保护作用,这种保护作用体现在NO能促进细菌的耐药及在氧化应激和压力应激时对微生物的保护等方面。本文综述了NO对微生物生长影响作用的两面性及其机制的研究进展。 |
| 关键词: 一氧化氮 微生物 两面性 |
| DOI：10.3724/SP.J.1008.2010.01356 |
| 投稿时间：2010-04-07修订日期：2010-05-05 |
| 基金项目:国家自然科学基金(81072678, 30825041, 30630071, 30672626), 上海市教育发展基金会晨光计划(2007CG51). |
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| Influence of nitric oxide on growth of microorganisms: a double-edged sword |
| LI De-dong, WANG Yan, LI Ying*, JIANG Yuan-ying* |
| (New Drug R & D Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| \[Abstract\]Recently increasing functions of nitric oxide (NO) has been discovered. Researchers around the world have reported that NO plays an important role in the anti-microbial infection; however, more recent studies have found that NO also protect the growth of microorganisms, for example, it can facilitate drug resistance of bacteria and it can protect microorganisms from oxidative stress and pressure. This paper reviews both positive and negative roles of NO on microbial growth and the related mechanisms. |
| Key words: nitric oxide microorganism two-side |
