| 摘要: |
| 肝脏是体内糖脂代谢的重要器官,转录因子碳水化合物反应元件结合蛋白(ChREBP)是调节肝脏糖酵解及脂肪合成的重要转录因子。ChREBP与Max样蛋白X以异二聚体的形式调控葡萄糖利用及转化为脂肪过程中大量基因的表达。在ob/ob小鼠肝细胞特异性敲除ChREBP基因后能明显改善其脂肪肝及胰岛素抵抗。阐明ChREBP对糖脂代谢的调控机制及其生物学功能,可进一步解释葡萄糖诱导脂肪形成的过程,并有望为脂肪肝等代谢性疾病的干预治疗提供新的思路。本文对ChREBP的结构特征、调控机制、生物学功能及其与疾病的关系等最新进展进行综述。 |
| 关键词: 碳水化合物反应元件结合蛋白 糖酵解 脂肪生成 脂肪肝 |
| DOI：10.3724/SP.J.1008.2011.0318 |
| 投稿时间：2010-07-14修订日期：2010-10-28 |
| 基金项目:国家高新技术发展规划("863"计划) |
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| Regulatory role of carbohydrate response element binding protein on hepatic glycolysis and lipogenesis |
| ZHOU Lu-ting, ZHANG Wei-ping* |
| (Department of Pathophysiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| The liver is the major site of carbohydrate metabolism and lipogenesis. The transcription factor ChREBP is a major mediator of glucose action in the control of hepatic glycolysis and lipogenesis. In the form of heterodimer with its partner Mlx, ChREBP regulates glucose-responsive genes in the liver and a family of genes required for glucose utilization and de novo lipogenesis. Liver-specific inhibition of ChREBP in ob/ob mice can improve hepatic steatosis and insulin resistance. In this review，we introduced the molecular structure, biological function, and regulatory mechanisms of ChREBP, as well as its relevance with metabolic diseases |
| Key words: carbohydrate response element binding protein glycolysis lipogenesis fatty liver |
