| 摘要: |
| [摘要]目的探讨血清胱抑素C、超敏C反应蛋白(hs-CRP)和尿微量白蛋白对痛风患者早期肾功能损伤的诊断价值。方法将100例痛风患者和50例健康志愿者分成3组：急性发作期组50例、间歇期组50例、健康对照组50例；采用全自动生化仪检测各组研究对象血清超敏C反应蛋白(hs-CRP)、胱抑素C(Cys-C) 和尿肌酐(Cr)水平,用免疫荧光分析仪测定尿微量白蛋白(mALB),分析各组检测结果。结果急性发作期组、间歇期组、健康对照组的mALB/Cr\[mg/(g·Cr)\]、hs-CRP(mg/L)和Cys-C(mg/L)分别为：11.45±3.55、5.15±1.98、2.62±0.83；8.96±1.78、3.28±1.23、0.93±0.26；3.89±0.76、1.91±0.57、0.78±0.22；急性发作期组、间歇期组mALB/Cr、hs-CRP和Cys-C均高于健康对照组,组间比较差异有统计学意义(P<0.05),且发作期组各指标均高于间歇期组(P<0.05)；87%的痛风患者存在hs-CRP+Cys-C+mALB/Cr异常。结论联合测定mALB/Cr、hs-CRP、Cys-C可能有助于评判痛风患者早期肾功能损伤。 |
| 关键词: 尿微量白蛋白 胱抑素C C反应蛋白质 肾功能损伤 痛风 |
| DOI：10.3724/SP.J.1008.2010.01198 |
| 投稿时间：2010-07-08修订日期：2010-08-07 |
| 基金项目:南京军区科技攻关基金(07M016). |
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| Diagnostic value of serum Cys-C, hs-CRP, and urine mALB for early renal injury in gonty patients |
| REN Chuan-lu1*, JIANG Tian-ru2 , GAO Chun3 |
| (1. Department of Laboratory Medicine, No.100 Hospital of PLA, Suzhou 215007, Jiangsu, China; 2. Department of Internal Medicine, No.100 Hospital of PLA, Suzhou 215007, Jiangsu, China; 3. Department of Laboratory Medicine, First Affiliated Hospital of Suzhou University, Suzhou 215006, Jiangsu, China) |
| Abstract: |
| [Abstract]ObjectiveTo explore the diagnostic value of serum Cys-C, hs-CRP, and urine mALB for early renal injury in gonty patients.MethodsA total of 100 gonty patients and 50 healthy volunteers were divided into 3 groups: acute phase group (n=50), intermittent group (n=50), and healthy control group (n=50) . The serum Cys C,hs-CRP,and urine creatinine were determined by automatic chemistry analyzer and urine mALB by immunofluorometer equipment, and the results were analyzed in each group.MethodsThe results of mALB/Cr(mg/\[g·Cr\]), hs-CRP(mg/L), and Cys-C(mg/L)in acute phase group were 11.45±3.55, 5.15±1.98, and 2.62±0.83, in intermittent group were 8.96±1.78, 3.28±1.23, and 0.93±0.26, and in healthy volunteer group were 3.89±0.76, 1.91±0.57, and 0.78±0.22, respectively. The values of the above three parameters in the acute phase and intermittent groups were significantly higher than those in the healthy control group (P<0.05); and the values in the acute phase group were significantly higher than those in the intermittent group (P<0.05).The abnormal rate of hs-CRP+Cys-C+mALB/Cr was 87% in gonty patients.MethodsSimultaneous determination of mALB/Cr, hs-CRP, and Cys-C can help to assess the early renal injury in gonty patients. |
| Key words: urine mALB cystatin C C-reactive protein kidney functional injury gout |
