| 摘要: |
| NOB1基因是新发现的一个与细胞周期及转录调节有密切关系的基因。NOB1编码的蛋白质包括一个PIN(PilT amino terminus)结构域和一个ZNRD1(锌带)结构域,PIN结构域和转录相关，而ZNRD1结构域在细胞周期调节中起重要作用。研究发现,NOB1与胃癌、食管癌、卵巢癌等肿瘤的发生发展有密切关系。本文主要就NOB1基因特点及其在肿瘤发生发展中的作用作一综述。 |
| 关键词: NOB1基因 蛋白酶体 细胞周期蛋白 肿瘤 |
| DOI：10.3724/SP.J.1008.2011.0432 |
| 投稿时间：2010-07-10修订日期：2010-09-21 |
| 基金项目: |
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| NOB1 gene and tumors |
| DONG Bo,ZOU Shao-wu,AI Kai-xing* |
| (Department of General Surgery, Sixth People’s Hospital of Shanghai, Shanghai Jiaotong University, Shanghai 200233, China) |
| Abstract: |
| NOB1 is a newly found gene regulating the function of the 26S proteasome, cell cycle and gene transcription.NOB1 contains a zinc ribbon domain and a PIN domain. Recent studies have indicated that the PIN domain is related to gene transcription and the zinc ribbon domain plays an important role in regulating cell cycle. It has also been found that NOB1 is closely associated with development and progression of gastric, esophageal, and ovarian cancer. The paper reviews the role of NOB1 in the development and progression of tumors. |
| Key words: NOB1 gene proteasome cyclins neoplasms |
