| 摘要: |
| 糖尿病周围神经病变是糖尿病最常见的并发症之一。胰高血糖素样肽-1(glucagon-like peptides 1, GLP-1)在控制血糖、保护神经、改善微循环、抗氧化应激及调节脂质代谢等方面发挥重要作用,可能与糖尿病周围神经病变的发生、发展密切相关,是目前相关研究的热点。本文就GLP-1与糖尿病周围神经病变的相关性及其作用机制研究进展作一综述。 |
| 关键词: 胰高血糖素样肽1 糖尿病周围神经病变 发病机制 |
| DOI：10.3724/SP.J.1008.2011.0329 |
| 投稿时间：2010-08-12修订日期：2011-02-01 |
| 基金项目:国家自然科学基金面上项目(30872416),上海市科委自然科学基金(10ZR1439400). |
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| Glucagon-like peptide-1 alleviating peripheral neuropathy in diabetic patients: advance in mechanism |
| WEN Xu-dong1, TANG Wei2, LIU Zhi-min2* |
| (1. School of Graduate Students, Second Military Medical University, Shanghai 200433, China; 2. Department of Endocrinology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Peripheral neuropathy is a common complication of patients with diabetes mellitus.Glucagon-like peptide-1 (GLP-1) is known to play important roles in glucose control, neural protection, improving microcirculation, anti-oxidation and lipid metabolism; it is thought to be closely related to the development and progression of diabetic peripheral neuropathy, and it has become a focus of study in the area. This paper introduces the recent researches concerning the association of GLP-1 with diabetic peripheral neuropathy and the related mechanism. |
| Key words: glucagon-like peptide 1 diabetic peripheral neuropathy pathogenesis |
