| 摘要: |
| \[摘要\]Lin28是一种高度保守的RNA结合蛋白,可以与miRNA家族中let-7家族的前体RNA的终末环相结合,并阻断let-7的成熟过程。Lin28/let-7通路参与了干细胞的功能及肿瘤的发生。将Lin28、OCT4、SOX2、NANOG转入成人的体细胞中,可以将其逆分化为多能干细胞。Lin28/Lin28B高表达的肿瘤多呈现低分化,预后较差。 |
| 关键词: Lin28基因 干细胞 肿瘤 |
| DOI：10.3724/SP.J.1008.2011.0206 |
| 投稿时间：2010-08-29修订日期：2010-12-17 |
| 基金项目:国家“863”高技术研究发展计划（2007AA02Z483）, 国家自然科学基金(30973076), 上海市启明星追踪项目 (09QH1402900). |
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| Function of Lin28: an advance |
| CHEN Chao, CHEN Ju-xiang* |
| (Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003,China) |
| Abstract: |
| \[Abstract\]Lin28 is a highly conservative RNA-binding protein. It can bind to the terminal loop of the precursor of let-7 family miRNAs and block the maturation of let-7. Lin28/let-7 signal pathway is involved in the stem cell pluripotency and tumor development. Combined transfection of Lin28, OCT4, SOX2, and NANOG can reprogram human somatic cells into pluripotent stem cells. Tumors with high expression of Lin28/Lin28B are often poorly differentiated and have poor prognoses. |
| Key words: Lin28 gene stem cells neoplasms |
