| 摘要: |
| 血管紧张素(angiotensin, Ang)-(1-7)是肾素血管紧张素系统中除AngⅡ以外，另一种重要的调节肽，主要作用于Mas受体发挥作用。Ang-(1-7)通过与其Mas受体的结合，发挥血管扩张和抗细胞增殖等作用；与AngⅡ及其AT1受体结合产生的血管收缩、血压升高、细胞增殖、尿钠潴留等作用相抗衡。近年来研究发现，Ang-(1-7)及其Mas受体在局部组织生理功能中具有积极作用，在多种疾病病理过程中具有保护作用。 |
| 关键词: Ang-(1-7) Mas受体 局部组织 疾病 |
| DOI：10.3724/SP.J.1008.2011.0667 |
| 投稿时间：2010-09-06修订日期：2011-03-10 |
| 基金项目:上海市卫生系统百名跨世纪优秀学科带头人培养基金 |
|
| Advances on beneficial effects of Angiotensin-(1-7) and its Mas receptor |
| DU Hui,MIAO Chao-yu |
| (\[Acad J Sec Mil Med Univ,2011,32(6):667-671\]) |
| Abstract: |
| Angiotensin-(1-7) is an alternative metabolite of the renin-angiotensin system (RAS) with actions that oppose those of angiotensinⅡ, via its binding to a specific receptor known as Mas. This review focused on the evidence suggesting that angiotensin-(1-7) is beneficial to tissues, and the potential of this protective component of the RAS in therapeutics of several diseases. |
| Key words: Ang-(1-7) Mas tissues diseases |
