| 摘要: |
| 糖胺聚糖(glycosaminoglycan,GAG)是一类含有糖醛酸和氨基糖残基的重要生物大分子。在细胞表面和细胞外基质中存在着一些高亲和力的GAG结合细胞因子,如血管内皮生长因子(vascular endothelial growth factor,VEGF)、中期因子(midkine,MK)、骨桥蛋白(osteopontin,OPN)、肝素酶(heparanase,HPA)、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)。它们除了具有多种生物学作用外 |
| 关键词: 糖胺聚糖 细胞因子类 肿瘤 |
| DOI：10.3724/SP.J.1008.2011.0898 |
| 投稿时间：2011-02-14修订日期：2011-03-17 |
| 基金项目:国家科技重大专项课题(2008ZX10002-021). |
|
| Glycosaminoglycans-binding cytokines and tumor |
| XIONG Jun-ye,KANG Xiao-yan,YIN Zheng-feng* |
| (Molecular Oncology Laboratory, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China) |
| Abstract: |
| Glycosaminoglycans (GAGs) are a group of important large biological molecules containing a hexosamine and an uronic acid component. Glycosaminoglycans-binding cytokines, such as vascular endothelial growth factor, midkine, osteopontin, heparanase, and bas |
| Key words: glycosaminoglycan cytokines neoplasms |
