| 摘要: |
| 目的研究F 框/WD40 域蛋白7(FBXW7)、脂肪酸合成酶(FAS)、微小染色体维持蛋白7(MCM7)在大肠癌中的表达及临床意义。方法应用免疫组织化学法检测FBXW7、FAS、MCM7在大肠癌、腺瘤、正常黏膜组织中的表达。结果FBXW7在大肠癌、腺瘤、正常黏膜组织中的表达率分别为58.2%、75.0%、88.9%,大肠癌与正常黏膜组织之间差异具有统计学意义(P<0.05),且与大肠癌的分化程度(χ2=10.516,P=0.001)、淋巴结转移(χ2=4.489,P=0.034)、肿瘤直径(χ2=9.974,P=0.002)有关；FAS在大肠癌、腺瘤、正常黏膜组织中的表达率分别为94.3%、75.0%、55.6%,在大肠癌与正常黏膜之间的差异具有统计学意义(P<0.01),且与患者的年龄相关(χ2=7.643,P=0.006)；MCM7在大肠癌、腺瘤、正常黏膜组织的表达率分别为95.8%、66.7%、22.2%,两两比较差异均有统计学意义(P<0.01)。FBXW7与FAS、MCM7之间存在负相关关系(r=-0.276,P=0.008；r=-0.443,P=0.000),FAS、MCM7之间呈正相关关系(r=0.228,P=0.024)。结论FBXW7、FAS、MCM7有可能成为大肠癌早期诊断、判断预后的新指标及治疗靶点。 |
| 关键词: 结直肠肿瘤 FBXW7 FAS MCM7 免疫组织化学 |
| DOI：10.3724/SP.J.1008.2011.040 |
| 投稿时间：2010-09-28修订日期：2010-12-28 |
| 基金项目: |
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| Expression of F-box/WD repeat-containing protein 7, fatty acid synthase and minichromosome maintenance protein 7 in colorectal carcinoma and the related clinical significance |
| GENG Juan-juan1,WANG Gui-ji1*,PEI Ying-xin2,WU Jing-jing1,ZHANG Wen-ping1 |
| (1. Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China;;2. Department of Nutrition and Food Hygiene, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China) |
| Abstract: |
| ObjectiveTo study the expression of Fbox/WD repeatcontaining protein 7(FBXW7), fatty acid synthase (FAS) and minichromosome maintenance protein7 (MCM7) in colorectal carcinoma and the related clinical significance. MethodsImmunohistochemistry method was used to examine the expression of FBXW7, FAS and MCM7 in the colorectal carcinoma, colorectal adenoma and paracarcinoma normal mucosa tissues. ResultsThe positive rates of FBXW7 in the colorectal carcinoma, adenoma and normal tissues were 58.2%, 75.0%, and 88.9%, respectively, with significant difference found between the colorectal carcinoma and normal mucosa tissues (P<0.05); and FBXW7 expression was significantly correlated with the differentiation degree（χ2=10.516，P=0.001）, lymphatic metastasis （χ2=4.489，P=0.034） and the tumor size（χ2=9.974，P=0.002）. The positive rates of FAS in the colorectal carcinoma, adenoma and normal tissue were 94.3%, 75.0%, and 55.6%, respectively, with significant difference found between the colorectal carcinoma and normal mucosa tissues (P<0.01); and FAS expression was significantly correlated with the patient age(χ2=7.643，P=0.006). The positive rates of MCM7 in the colorectal carcinoma, adenoma and normal tissue were 95.8%, 66.7%, and 22.2%, respectively, with the difference being significant between the three groups (P<0.01). FBXW7 expression was negatively correlated with that of FAS and MCM7（r=-0.276，P=0.008；r=-0.443，P=0.000）, and FAS expression was positively correlated with MCM7 expression（r=0.228，P=0.024）. ConclusionFBXW7, FAS and MCM7 might be new markers for early diagnosis and prognosis prediction of colorectal carcinoma; they may also serve as new therapeutic targets for colorectal carcinoma. |
| Key words: colorectal neoplasms FBXW7 FAS MCM7 immunohistochemistry |
