| 摘要: |
| \[摘要\]目的探讨联合补充维生素C和E是否可以降低妊娠妇女先兆子的发病风险。方法计算机检索电子数据库建库以来至2010年10月关于妊娠妇女联合补充维生素C和E后妊娠结局的随机对照试验研究文献。研究结局为先兆子。采用RevMan 5.0.25软件对各项纳入研究的相对危险度(RR)及其可信区间进行合并,并进行异质性分析。结果共纳入10项研究,19 656例妊娠妇女(实验组9 823例,安慰剂对照组9 833例)。所有纳入研究、纳入的高质量研究、纳入的低质量研究的合并RR值(95%可信区间)分别为0.94 (0.80~1.11, P=0.49),1.02 (0.91~1.14,P=0.79)和0.40 (0.15~1.10,P=0.08)。结论妊娠期间联合补充维生素C和E不能显著降低先兆子的发病风险。 |
| 关键词: 先兆子 抗坏血酸 维生素E meta分析 |
| DOI：10.3724/SP.J.1008.2010.01206 |
| 投稿时间：2010-10-22修订日期：2010-11-05 |
| 基金项目: |
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| Combined vitamin C and E supplementation in preventing preeclampsia: a meta-analysis of randomized controlled trials |
| CAI Jun-ying*, CHEN Mei-jiao, LIN Qing |
| (Department of Obstetrics and Gynecology, Changle Hospital, Changle 350200, Fujian, China) |
| Abstract: |
| [Abstract]ObjectiveTo evaluate whether combined supplementation of vitamin C and E in pregnant women can reduce the risk for preeclampsia. MethodsElectronic databases were searched for randomized controlled trials investigating pregnancy outcomes in women following exposure to combined vitamin C and E supplementation since the establishment of the database to Oct. 2010. The end-point of the study was preeclampsia. The relative risk (RR) and confidence interval (CI) for each included studies were pooled and heterogeneity analysis was performed by using RevMan 5.0.25 software. MethodsTotally 10 studies involving 19 656 pregnant women at risk of preeclampsia were included, with 9 823 receiving vitamin C and E and 9 833 receiving placebo. The pooled RR values for preeclampsia in all studies, the studies with high quality, and the studies with low quality were 0.94 (95% CI of 0.80-1.11, P=0.49), 1.02 (95% CI of 0.91-1.14, P=0.79), and 0.40 (95% CI of 0.15-1.10, P=0.08), respectively. MethodsCombined vitamin C and E supplementation has no potential benefit in reducing the risk for preeclampsia. |
| Key words: pre-eclampsia ascorbic acid vitamin E meta-analysis |
