| 摘要: |
| 电离辐射可以导致机体免疫功能低下,对人员健康及放射病的治疗及预后有重要影响。树突状细胞(dendritic cell,DC)是机体最重要的抗原提呈细胞,是免疫反应的启动者和调控者,研究电离辐射对DC的影响不仅可以为辐射导致免疫抑制的机制提供依据,也可以通过改善照后DC的功能状态进行辐射防护研究,基于DC的癌症疫苗联合放射治疗也为肿瘤的治疗提供了新的思路。本文综述了电离辐射对DC存活率、表型、抗原提呈功能和迁移能力、分泌细胞因子的影响,以及这些辐射生物效应产生的分子机制,同时也探讨了DC疫苗结合放疗在肿瘤治疗中的一些研究进展,旨在从免疫学的角度为辐射防护提供新的思路,也为改善受照人员免疫功能状态提供文献支持。 |
| 关键词: 树突细胞 电离辐射 免疫抑制 肿瘤 |
| DOI：10.3724/SP.J.1008.2011.01133 |
| 投稿时间：2011-02-20修订日期：2011-07-15 |
| 基金项目: |
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| Effects of ionizing radiation on dendritic cells |
| YANG Yan-yong,CAI Jian-ming* |
(Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Ionizing radiation (IR) can cause immune dysfunction, resulting in severe damages to human health and affecting the recovery of radiation injury. Dendritic cells (DCs) are the most potent antigen presenting cells (APCs), which are also the initiator and modulator of immune system. Studies on the radiation effects of DCs can not only help to understand the mechanism of radiation-induced immunosuppression, but also facilitate the research on DCs function for radioprotection. DC-based cancer vaccine combined with radiotherapy also provides new insights into cancer therapy. This paper reviews the influence of IR on the viability, phenotype, antigen presenting function and migration capacity, cytokine secretion of DCs, as well as the underlying mechanism. We also review some advances in tumor therapy by combining DC vaccine with radiotherapy, hoping to provide reference for studying radiation-induced immunosuppression and radioprotection. |
| Key words: dendritic cells, ionizing radiation, immunosuppression, cancer therapy |
