| 摘要: |
| 目的：研究非去极化肌松药罗库溴铵和顺式阿曲库铵对分娩期SD大鼠离体子宫平滑肌收缩功能的影响。方法：分娩期SD大鼠，脱颈椎法处死，取子宫平滑肌组织，放置离体实验装置中，浴槽中给予去极化肌松药，并通过换能器转换，将平滑肌收缩情况记录于多道生理信号分析仪，后分别用缩宫素和肌松药拮抗剂新斯的明作用于平滑肌，并分别记录收缩值。数据采用SPSS17处理，SigmaPlot11作图，比较药物作用下平滑肌收缩影响情况（P＜0.05）。结果：罗库溴铵和顺式阿曲库铵对分娩期SD大鼠离体子宫平滑肌收缩具有明显抑制作用(P＜0.05),罗库溴铵与顺阿组间无统计学差异。缩宫素和新斯的明可增强平滑肌收缩力（P＜0.05）。结论：罗库溴铵和顺式阿曲库铵具有M受体拮抗作用，对分娩期SD大鼠离体子宫平滑肌收缩功能可产生抑制作用，缩宫素和新斯的明可缓解非去极化肌松药对离体子宫平滑肌收缩抑制。妇产科急重症全麻患者应考虑避免肌松药的残余作用造成的宫缩乏力可能。 |
| 关键词: 非去极肌松药 子宫平滑肌 收缩 大鼠，SD |
| DOI：10.3724/SP.J.1008.2011.0677 |
| 投稿时间：2011-02-27修订日期：2011-06-04 |
| 基金项目:2008年普陀区卫生系统自主创新科研资助项目 |
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| The Effect of Rocuronium and Cis-atracurium on Uterine Smooth Muscle Contraction in Isolated Rat at the Labor Stages |
| ZHONG Weiguo,Zhu Hai |
| (Obstetrics and Gynecology Department of Shanghai PUTUO District Maternity and Child Health Hospital;Anesthesiology Department of Shanghai PUTUO District Maternity and Child Health Hospital) |
| Abstract: |
| Objective： To study the effect of the non-depolarizing muscle relaxants rocuronium and cis-atracurium on uterine smooth muscle contraction of isolated rat at the labor stages. Methods：SD rats at labor stages were killed by cervical off. The uterine smooth muscle tissue was placed into the in vitro devices. The depolarized muscle relaxants were given to the bath and converted by the transducer. The value of the smooth muscle contraction were recorded in the multichannel physiological signal analysis system. The value of smooth muscle contraction were recorded before the oxytocin antagonist and muscle relaxant, neostigmine were used in smooth muscle. For comparison of the drugs, the SPSS17 was used in data processing of smooth muscle contraction（ P＜0.05）. Results： Rocuronium and cis-atracurium had significantly inhibited effect on the uterine smooth muscle of isolated rat at labor stages. There was no significant difference in statistics between the two groups（ P＜0.05）. This contractil inhibition could be eased by oxytocin and neostigmine（ P ＜0.05）. Conclusion： Rocuronium or cis-atracurium prossessed antagonism for M receptor, so they could produce inhibitory effect on the uterine smooth muscle of isolated rat at laboe stages. Oxytocin and neostigmine could relax uterine smooth muscle inhibition caused by non-depolarizing muscle relaxants. Acute severe obstetrics patients in general anesthesia with muscle relaxants should be taken to avoid residual effects may be due to uterine inertia. |
| Key words: Neuromuscular Depolarizing Agents Myometrium Uterine Contraction rat,SD |
