| 摘要: |
| 目的研究妇科盆腔根治术后应用低分子右旋糖酐氨基酸预防静脉血栓病的可行性。方法随机对照研究276例妇科盆腔根治术后有静脉血栓病高危因素的患者,观察预防性应用低分子右旋糖酐氨基酸组及生理盐水对照组有无静脉血栓形成,并分析血常规、凝血酶原时间(PT)、凝血酶时间(TT)、活化的部分凝血酶时间(APTT)、D-二聚体、凝血因子Ⅱ促凝活性、全血黏度等指标。结果手术后,与对照组相比,预防性应用低分子右旋糖酐氨基酸组静脉血栓发生率及D-二聚体、凝血因子Ⅱ促凝活性、全血黏度明显下降(P<0.05),而凝血功能PT、TT、APTT水平无明显延长。 结论预防性使用低分子右旋糖酐氨基酸可改善妇科盆腔根治术患者的凝血功能,减少血栓性疾病的发生率,提示应用低分子右旋糖酐氨基酸预防妇科盆腔根治术后静脉血栓病安全有效。 |
| 关键词: 低分子右旋糖酐氨基酸 盆腔根治术 预防和控制 静脉血栓病 |
| DOI：10.3724/SP.J.1008.2011.0561 |
| 投稿时间：2011-03-06修订日期：2011-04-15 |
| 基金项目: |
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| Preventive effect of low molecular weight dextranon and amino acid injection against venous thromboembolism after radical correction of cavitas pelvis |
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| Abstract: |
| Objective To study the effect of low molecular dextran on venous thromboembolism of patients after radical correction of cavitas pelvis. Method This propective randomized case-control study consisted of two hundred and seventy six postoperative patients with high risk of venous thromboembolism,low molecular dextran was used as prophylactics for venous thromboembolism, and the change of blood routine, coagulation function and morbidity of deep vein thrombosis were analyzed. Result After operation, D-dimer、Coagulation Factor Ⅱ and blood viscosity in patients using low molecular dextran was lower than those in control group (P<0.05). Conclusion Coagulation funtion can be improved by using low molecular dextran after radical correction of cavitas pelvis,postoperative venous thromboembolism can be decreased. |
| Key words: low molecular dextran radical correction of cavitas pelvis Prevention & control venous thromboembolism |
