| 摘要: |
| 近年来,深部真菌感染发病率急剧升高,且具有极高的致死率。而临床上现有的抗真菌药物的耐药现象十分严重,寻求新的治疗手段成为当前研究的热点。本文从作用于新靶点的抗真菌药物、采取联合用药方式进行抗真菌治疗以及研发真菌疫苗3大方面进行综述。 |
| 关键词: 深部真菌感染 新药 联合药物疗法 真菌疫苗 |
| DOI：10.3724/SP.J.1008.2012.00558 |
| 投稿时间：2011-12-12修订日期：2012-03-10 |
| 基金项目:上海市教育发展基金(2007CG51)；国家自然科学基金(项目批准号81072678，30672626, 30825041, 30630071)；国家科技部科技重大专项(项目批准号2011ZX09102-002-01)；上海市科技重点项目(项目批准号：10431902200). |
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| Novel thoughts on treatment of invasive fungal infections |
| ZHU Liang-hua1,2,LI De-dong2,WANG Yan2*,JIANG Yuan-ying2* |
(1. Department of Traditional Chinese Medicine, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian, China
2. New Drug R & D Center,School of Pharmacy,Second Military Medical University,Shanghai 200433,China
*Corresponding author.) |
| Abstract: |
| The incidence of invasive fungal infections rose rapidly during the past years, which resulted in high mortality. What makes it worse is that drug resistance has also become a very serious problem in clinical practice. Searching for the novel therapy strategies is now a focus of related scientists. This article reviews the treatment of invasive fungal disease from the following three aspects: the development of anti-fungal agents aiming new targets, combined drug therapy and development of antifungal vaccines. |
| Key words: invasive fungal infections new drugs combination drug therapy antifungal vaccine |
