| 摘要: |
| 干细胞有无限制自我更新以及分化成多种祖细胞的能力。间充质干细胞(MSCs)能特异地向多种肿瘤以及它们的转移灶迁移，并且它们的迁移是遍及全身的。借助这一特性，基因修饰MSCs可用作特异性靶向药物的载体并表达抗癌因子以抑制肿瘤生长。然而，许多问题和确切的机制尚待解答。本文主要回顾MSCs归巢的机制、MSCs作为载体用于肿瘤治疗以及MSCs与无活性药物载体相比的优缺点。MSCs作为载体可能成为一种细胞治疗，在未来的肿瘤治疗中发挥作用。 |
| 关键词: 间充质干细胞 肿瘤 药物载体 归巢 |
| DOI：10.3724/SP.J.1008.2011.01030 |
| 投稿时间：2011-04-14修订日期：2011-06-22 |
| 基金项目: |
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| Mesenchymal stem cells: a delivery vehicle for cancer therapy |
| XU Ying-long,WANG Jian* |
(Department of Urology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, Guangdong, China
*Corresponding author.) |
| Abstract: |
| Stem cells possess unlimited self-renewal properties and the ability to produce multiple differentiation progenitors. Mesenchymal stem cells (MSCs) can specifically migrate to multiple kinds of tumors and their metastases in a systemic manner(to all parts of the body). Therefore genetically modified MSCs can serve as vehicle of anticancer factors to inhibit growth of tumor. But many questions remain to be answered and the precise mechanisms remain unclear. This paper reviews the mechanism of MSC homing, MSCs as delivery vectors for cancer therapy and its advantages over traditional drug vehicle. MSCs as delivery vectors can be used for cellular therapy in future cancer treatment. |
| Key words: mesenchymal stem cells neoplasms drug carriersi homing |
