| 摘要: |
| 目的探讨炎症因子在冠状动脉微栓塞(CME)后心肌组织中的表达及核因子(B(NF-κB)抑制剂的干预作用。方法清洁级雄性SD大鼠88只，其中64只经左心室内注射自体微血栓、同时短暂夹闭主动脉建立大鼠CME模型后，随机分为未治疗组及NF-κB抑制剂二硫代氨基甲酸吡咯烷(PDTC)干预组，分别于术后1、3、7、14 d处死；余24只为假手术组。原位杂交及免疫组织化学染色检测肿瘤坏死因子α(TNF-α)、白介素6(IL-6)及细胞间黏附因子1(ICAM-1)等炎症因子在心肌中的空间分布及动态变化。结果CME炎症并 |
| 关键词: 冠状动脉微栓塞 NF-κB 肿瘤坏死因子α 白介素6 细胞黏附分子 |
| DOI：10.3724/SP.J.1008.2011.0851 |
| 投稿时间：2011-05-19修订日期：2011-06-22 |
| 基金项目:南京军区医学科技创新基金(09MA104). |
|
| Expression of inflammatory factors in myocardium following coronary microembolization and effect of NF-κB inhibitor on the expression in rats |
| LI Shu-mei1*,CHEN Liang-long2,ZENG Kai2,WU Jin-shou2 |
| (1. Department of Cardiology,No. 476 Hospital, Fuzhou General Hospital, Nanjing Military Area Command, Fuzhou 350001, Fujian, China;2. Department of Cardiology, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian, China) |
| Abstract: |
| ObjectiveTo investigate the expression of inflammatory factors in myocardium following coronary microembolization (CME) and effect of NF-κB inhibitor on the expression. MethodsCME models were created in 64 rats by injecting homologous microthrombotic part |
| Key words: coronary microembolization NF-κB tumor necrosis factor-alpha interleukin-6 cell adhesion molecules |
