| 摘要: |
| 创伤性视神经损伤(TON)是在外力作用下引起的视神经损伤,尚缺乏确切的治疗方法,预后较差,是颅脑外伤致残率较高的主要原因之一。随着神经生物学和分子生物学研究的进展,视神经损伤和再生的研究成为神经科学研究的热点和难点。本文针对各种创伤性视神经损伤动物模型的优缺点进行综述,为进一步建立理想的动物模型及进行前瞻性实验研究提供参考。 |
| 关键词: 视神经损伤 动物模型 |
| DOI：10.3724/SP.J.1008.2012.00429 |
| 投稿时间：2011-09-05修订日期：2011-11-27 |
| 基金项目:国家自然科学基金 |
|
| Animal models of traumatic optic neuropathy: recent advance |
| LIN Chao,DONG Yan,HOU Li-jun* |
(Department of Neurosurgery, Changzheng Hospital, Shanghai Neurosurgical Institute, Second Military Medical University, Shanghai200003, China
*Corresponding author.) |
| Abstract: |
| Traumatic optic neuropathy (TON) is caused by blunt trauma and has poor prognosis due to lack of effective treatments, and it is a main reason for high rate of disability after traumatic brain injury. Progression in neurobiology and molecular biology has made it a research focus to study optic nerve damage and regeneration. This article reviews the advantages and disadvantages of various animal TON models, paving a way for establishing ideal TON models and for future prospective researches. |
| Key words: optic nerve injuries animal models |
