| 摘要: |
| 目的探讨盐酸非那嗪奈 (fenazinel dihydrochloride, FD) 对易卒中型自发性高血压大鼠 (stroke-prone spontaneously hypertensive rat, SHRSP) 脑卒中的预防和治疗作用。方法7周龄大小的SHRSP,令其每日摄入约1 g食盐以促进脑卒中的发生,同时每日腹腔注射剂量为1、3、10 mg/kg的FD。观察SHRSP脑卒中发生时间、存活时间和脑卒中后的神经症状的改变。结果FD可延缓SHRSP的脑卒中发生时间,延长动物脑卒中发生后的存活时间(P<0.05或P<0.01),低、中剂量还可减轻动物发生脑卒中后的神经症状(P<0.05或P<0.01)。结论FD对SHRSP有一定的抗脑卒中作用。 |
| 关键词: 盐酸非那嗪奈 卒中 易卒中型SHR大鼠 |
| DOI：10.3724/SP.J.1008.2011.00 |
| 投稿时间：2011-09-06修订日期：2011-11-22 |
| 基金项目:国家重点基础研究发展计划 (“973”计划,2009CB521900). |
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| Protective effects of fenazinel dihydrochloride against stroke in stroke-prone spontaneously hypertensive rats |
| ZHAO Ting1,ZHANG Wei2,SHEN Fu-ming1* |
(1. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2. Department of Pharmacy, The Second Out-patient Department, General Logistics Department of PLA, Beijing 100071, China
*Corresponding author.) |
| Abstract: |
| ObjectiveTo investigate the protective effect of fenazinel dihydrochloride (FD) against stroke in stroke-prone spontaneously hypertensive rats (SHRSP). MethodsSeven-week old male SHRSP were fed with NaCl 1 g/d to induce stroke. Meanwhile, FD was injected intraperitoneally at 1, 3, and 10 mg/(kg·d). The stroke onset time, survival period after stroke, and neuronic deficit score after stroke were observed. ResultsFD delayed the onset of stroke in SHRSP and prolonged the survival of the animals. Furthermore, low and medium doses FD also improved the neuronal deficit score after stroke. ConclusionOur data suggest that FD has protective effect in SHRSP. |
| Key words: fenazinel dihydrochloride stroke stroke-prone SHR rats |
