| 摘要: |
| 星形胶质细胞升高基因1（astrocyte elevated gene 1, AEG-1）作为重要的癌基因之一,目前已被证实在多种肿瘤的发生发展过程中发挥关键性作用。近十年来研究表明AEG-1在神经母细胞瘤、黑素瘤、肝癌、乳腺癌、前列腺癌等几乎所有器官的恶性肿瘤中均有不同程度过表达,在肿瘤细胞增殖、促进血管生成、肿瘤转化、侵袭和转移以及化疗耐药等方面发挥多重调节作用,其机制涉及到PI3K/Akt、NF-κB等多个信号通路。本文主要综述近年来AEG-1在肿瘤发生发展过程中多重调节作用的相关研究进展,以及将其作为恶性肿瘤治疗新靶点的应用前景。 |
| 关键词: 星形胶质细胞升高基因1 血管生成 肿瘤转移 化疗耐药 |
| DOI：10.3724/SP.J.1008.2012.00668 |
| 投稿时间：2011-10-15修订日期：2011-12-06 |
| 基金项目: |
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| Astrocyte elevated gene 1 as a multifunctional regulator in cancer progression |
| GU Wen-wen1,CAO Yong-bing2,JIANG yuan-ying2*,GONG Xiao-jian1* |
(1. Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
2. R & D Center of New Drug, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding authors.) |
| Abstract: |
| Astrocyte elevated gene 1 (AEG-1), an important oncogene, has been confirmed to play a crucial role in progression (invasion, metastasis, angiogenesis and chemoresistance, etc) of multiple cancers. Over the past decade, studies have shown that AEG-1 is overexpressed in cancers involving almost all organs, including neuroblastoma, melanoma, HCC, breast, prostate cancer, etc. Moreover, AEG-1 is associated with multiple pathways including PI3K/Akt and nuclear factor-κB (NF-κB). This review mainly outlines the multiple regulating role of AEG-1 in the development and progression of tumor and to discuss its role as a novel target for treatment of malignant tumors. |
| Key words: astrocyte elevated gene 1 angiogenesis neoplasm metastasis drug resistance |
