| 摘要: |
| 聚乳酸-羟基乙酸(PLGA)骨组织工程支架在骨损伤修复和再造方面有着重要的应用, 但由于PLGA亲水性差, 不利于种子细胞在支架上的黏附和增殖。RGD(精氨酸-甘氨酸-天冬氨酸, Arg-Gly-Asp)肽修饰PLGA支架后, 材料的细胞亲和性得到了有效改善, 促进了种子细胞黏附和增殖。本文就近年来RGD修饰的PLGA骨组织工程材料的相关研究作一综述。 |
| 关键词: 聚乳酸羟基乙酸 骨代用品 组织工程 RGD肽 |
| DOI：10.3724/SP.J.1008.2012.095 |
| 投稿时间：2011-10-15修订日期：2011-12-29 |
| 基金项目:国家自然科学基金(81072601). |
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| RGD-modified polylactide-co-glycolic acid tissue engineering scaffolds for bone regeneration: an advance |
| TAO Chun,CHEN Yan*,ZHONG Yan-qiang* |
(Department of Pharmaceutical Science, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Polylactide-co-glycolic acid (PLGA) tissue engineering scaffolds play an important role in the regeneration of bone and cartilage. Due to the poor hydrophilicity of PLGA, it is difficult for cells to attach to the scaffolds. Modification by RGD (Arg-Gly-Asp) peptides can effectively improve the cellular affinity of PLGA and adhesion and proliferation of the seed cells. This review summarizes the recent progress in PLGA tissue engineering scaffolds modified by RGD peptides. |
| Key words: polylactide-co-glycolic acid bone substitutes tissue engineering RGD peptide |
