| 摘要: |
| 丙型肝炎病毒(hepatitis C virus,HCV)入侵宿主细胞是由多种受体分子介导的多步骤过程,其中B族Ⅰ型清道夫受体(SR-BⅠ/SCARB1) 被认为是最先与HCV作用的受体。SR-BⅠ能够与HCV包膜糖蛋白E2相结合,在此过程中位于E2蛋白氨基末端的高变区1(hypervariable region 1,HVR1)起关键作用。SR- BⅠ与HCV的相互作用不仅能够介导HCV的细胞入侵,还能降低抗体对HCV的中和作用,有助于HCV的免疫逃避。因此,深入研究SR- BⅠ在HCV入侵细胞过程中的作用机制,有望发现在HCV感染的初始环节能够高效地阻断HCV入侵细胞的靶分子,从而预防和治疗HCV的感染。本文就SR-BⅠ的生物学特性、SR-BⅠ与HCV的相互作用对病毒入侵细胞的影响及机制等方面的最新进展作一综述。 |
| 关键词: 丙型肝炎病毒 B族Ⅰ型清道夫受体 高变区1 入侵 |
| DOI：10.3724/SP.J.1008.2012.00425 |
| 投稿时间：2011-10-24修订日期：2012-03-02 |
| 基金项目:国家传染病重大科技专项课题(2012ZX10002-003,2012ZX10004801-002-005), 上海市重点学科建设项目(B901), 军队科技重大专项课题(AWS11C001). |
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| Role of scavenger receptor class B type Ⅰ in cell entry of hepatitis C virus |
| XU Qing-qiang,QI Zhong-tian* |
(Department of Microbiology, College of Basic Medical Sciences, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, Shanghai200433, China
*Corresponding author.) |
| Abstract: |
| Hepatitis C virus (HCV) cell entry is a multistep process mediated by various receptors. Among these receptors, the scavenger receptor class B type Ⅰ (SR-BⅠ) is the one considered to be the first to interact with HCV. SR-BⅠ can bind to HCV envelope glycoprotein E2, in which the hypervariable region 1 (HVR1) segment locating at the N-terminus of E2 protein plays a critical role. The interaction of SR-BⅠ with HCV can not only mediate HCV cell entry, but also attenuate neutralization activity of antibodies against E2 protein, contributing to the HCV immune evasion. Therefore, studying the mechanism of HCV/SR-BⅠinteraction during cell entry can help to identify important targets in the initial step of viral infection, contributing to prevention and treatment of HCV infection. This paper reviews the current knowledge on the biological characteristics of SR-BⅠ and mechanisms of HCV cell entry mediated by virus/SR-BⅠinteraction. |
| Key words: hepatitis C virus scavenger receptor class B type Ⅰ hypervariable region1 entry |
