| 摘要: |
| 白假丝酵母菌是临床最常见的条件致病真菌之一,近年来引起人们的广泛关注。白假丝酵母菌在侵染宿主时会遇到各种环境条件如温度、pH、渗透压及氧化损伤等的改变,如何适应这些环境条件对白假丝酵母菌在宿主中生存及发挥其致病性至关重要。本文总结了白假丝酵母菌应对宿主的应激反应通路,提示进一步深入研究白假丝酵母菌应激反应通路有助于发现新的抗真菌药物靶点。 |
| 关键词: 白假丝酵母菌 宿主与病原体相互作用 应激 |
| DOI：10.3724/SP.J.1008.2013.00328 |
| 投稿时间：2012-08-21修订日期：2012-12-24 |
| 基金项目:国家自然科学基金青年基金(31000079),上海市基础研究重点项目(10JC1417500). |
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| Stress response of Candida albicans to human hosts |
| KANG Ye,YAN Lan*,JIANG Yuan-ying* |
(New Drug R&D Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Candida albicans (C.albicans), one of the most commonly-seen opportunistic fungal pathogen, has drawn great public health concern in recent years. C. albicans faces numerous challenges when entering human hosts, including temperature, pH, osmotic stress and oxidative damage. How to adapt to these challenges is critical to the survival and infection ability of C. albicans. This article summarizes the stress response pathways of C. albicans to human host, and it is suggested that studying the stress response pathways may help to find new antifungal targets for C. albicans. |
| Key words: Candida albicans host-pathogen interactions stress |
