| 摘要: |
| 结直肠癌是最常见的恶性肿瘤之一。流行病学和分子生物学研究表明炎症和结直肠癌发病之间存在着密切联系。目前关于炎症和结直肠癌发病有关的分子机制研究已有不少报道,但是尚不能完全阐释。若能发现结直肠癌发病的重要炎症基础,则可能为结直肠癌的预防和治疗提供新靶点。本文系统地对结直肠癌发病相关的炎症机制进行综述,以期为以后的进一步研究提供线索。 |
| 关键词: 炎症 结直肠肿瘤 炎症通路 致癌作用 |
| DOI：10.3724/SP.J.1008.2013.0078 |
| 投稿时间：2012-09-14修订日期：2012-11-12 |
| 基金项目:国家自然科学基金青年科学基金(81101640)，浙江省自然科学基金 (D2080011), 中央高校基本科研业务费专项资金. |
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| Role of inflammation in the carcinogenesis of colorectal cancer |
| XU Chun-xiao,ZHANG Yan,ZHU Yi-min* |
(School of Public Health, Zhejiang University, Hangzhou 310058, Zhejiang, China
*Corresponding author.) |
| Abstract: |
| Colorectal cancer is one of the most common malignant tumors. Previous epidemiological and molecular biological studies have suggested that inflammation plays a pivotal role in the pathogenesis of colorectal cancer. Moreover, many studies have been focused on molecular pathways of inflammation in colorectal cancer. However, the explicit mechanisms involved remain to be fully elucidated. The identification of the key inflammatory mechanisms may provide new targets for intervention and treatment of colorectal cancer. Here we reviewed the inflammatory mechanisms relevant to the carcinogenesis of colorectal cancer, hoping to cast new lights on future research. |
| Key words: inflammation colorectal neoplasms inflammatory pathway carcinogenesis |
