| 摘要: |
| 目的探讨心血管系统不同分子组成的ATP敏感钾通道(KATP)在降低去窦弓神经(SAD)大鼠血压波动性(BPV)中的作用。方法建立SAD大鼠模型,利用计算机化清醒自由活动大鼠血流动力学监测技术,观察非选择性KATP开放剂吡那地尔、Kir6.1/Sur2B和Kir6.1/Sur1选择性开放剂二氮嗪对SAD大鼠BPV 的影响;并观察用Kir6.1/Sur1选择性阻断剂5-羟基癸酸盐(5-HD)、Kir6.2/Sur2A选择性阻断剂HMR1098阻断KATP后,吡那地尔和二氮嗪对SAD大鼠BPV作用的改变。结果吡那地尔和二氮嗪能够降低SAD大鼠BPV(P<0.01),阻断Kir6.1/Sur1、Kir6.2/Sur2A后不改变吡那地尔和二氮嗪对BPV的降低作用。结论开放血管平滑肌细胞Kir6.1/Sur2B能够降低SAD大鼠的BPV。 |
| 关键词: 去窦弓神经 血压波动性 KATP通道 血管平滑肌 |
| DOI：10.3724/SP.J.1008.2012.001315 |
| 投稿时间：2012-10-15修订日期：2012-12-04 |
| 基金项目: |
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| Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats |
| ZHANG Wei1,ZHAO Xin-bin2,YANG Hong2,NI Min2* |
(1.Department of Pharmacy, The Second Out-patient Clinics, General Logistics Department of PLA, Beijing 100071, China
2.Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*Corresponding author.) |
| Abstract: |
| ObjectiveTo determine the role of different molecular compositions of KATP channels in reducing the blood pressure variability (BPV) in conscious,freely-moving sinoaortic denervated (SAD) rats. MethodsSAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective KATP openers (pinacidil) or Kir6.1/Sur2B and Kir6.1/Sur1 selective opener (diazoxide) on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6.1/Sur1 antagonist 5-hydroxydecanoic acid (5-HD) and selective Kir6.2/Sur2A antagonist (HMR1098). ResultsBoth pinacidil and diazoxide significantly decreased BPV in SAD rats (P<0.01), and pre-treatment with 5-HD+HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. ConclusionOpening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats. |
| Key words: sinoaortic denervated blood pressure variability KATP channels vascular smooth muscle |
