| 摘要: |
| β-抑制蛋白(β-arrestins)是一类介导受体脱敏的重要可溶性蛋白质,其生物功能多种多样,能调节细胞的增殖、生存、凋亡及基因转录过程。β-arrestins参与调节机体的炎症和免疫反应过程,抑制促炎转录因子NF-κB的基础活性,调节Toll样受体(TLR)/NF-κB信号转导通路对NF-κB的活化。β-arrestins参与多种炎症性疾病的发生发展,如炎症性肠病、类风湿关节炎、强直性脊柱炎和支气管哮喘等。β-arrestins通过多种途径调节其炎症反应,对于β-arrestins的研究将有助于揭示炎症性疾病的发病机制,为炎症性疾病的治疗提供新的思路。本文就近年来关于β-arrestins调控炎症性疾病的研究进展作一简要综述。 |
| 关键词: β-抑制蛋白类 NF-κB 炎症性疾病 |
| DOI： |
| 投稿时间：2013-02-25修订日期：2013-05-26 |
| 基金项目:国家自然科学基金 |
|
| β-arrestins in regulating inflammatory diseases: recent progress |
| CUI Mei jian,LIU Chong,CAI Guo jun* |
(Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| β-arrestins, important soluble proteins mediating receptor desensitization, have diverse biological functions, such as regulating cell proliferation, cell survival, apoptosis and gene transcription. β-arrestins regulate inflammatory and immune reactions by inhibiting the basal activity of pro-inflammatory transcription factor NF-κB and participating in Toll-like receptors (TLR)/NF-κB signal pathway-mediated NF-κB activation. β-arrestins are involved in the pathogenesis of various inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, asthma and so on. The study on β-arrestins will reveal the mechanisms of inflammatory diseases and provide new strategy for clinical treatment. Here we reviewed the recent progress on the role of β-arrestins in regulating the inflammatory diseases. |
| Key words: β-arrestins NF-κB inflammatory diseases |
