| 摘要: |
| 长链非编码RNA(long noncoding RNA, lncRNA)是一类长度超过200个核苷酸的非编码RNA分子,无蛋白质编码功能,以RNA形式在表观遗传学、转录及转录后等多种水平调控基因表达,在病理生理过程中起着重要的调节作用。近期研究证据显示,原发性肝癌等肝脏疾病中有多种lncRNA表达水平发生了变化,并在肝癌发生、发展及预后中起着重要的调控作用,本文主要就lncRNA在原发性肝癌等肝脏疾病中的机制研究作一综述。 |
| 关键词: 长链非编码RNA 肝细胞癌 乙型肝炎 肝再生 |
| DOI：10.3724/SP.J.1008.2013.00322 |
| 投稿时间：2013-01-13修订日期：2013-02-20 |
| 基金项目: |
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| Long noncoding RNAs in liver diseases: recent progress |
| LIN Pei-yi,WENG Ming-zhe,TANG Zhao-hui* |
(Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
*Corresponding author.) |
| Abstract: |
| Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nt with no protein coding capacity. LncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels, and they are deeply involved in biological and pathological changes. Recent evidences have shown changed expression of lncRNAs in viral hepatitis and hepatocellular carcinoma, and that they play important roles in the development, progression and prognosis of hepatic cancer. This review focuses on the mechanism of lncRNAs in hepatocellular carcinoma and other liver diseases. |
| Key words: long noncoding RNAs hepatocellular carcinoma hepatitis B liver regeneration |
