| 摘要: |
| 目的 探讨西藏高原地区胃癌发病特点。方法 对237例西藏地区胃癌住院患者临床资料回顾性分析，比较在性别、年龄、临床、内镜及病理组织学构成等方面特征。结果 资料显示男女之比为3.2∶1，237例患者以40-59岁年龄段(51.5%)最为多见，职业分布中以农民、干部所占比例最高(60.8%)；肿瘤好发部位为胃窦(68.4%)，内镜下形态主要表现为浸润型(82.3%)，低分化腺癌为最常见组织类型 (81.0%)，肿瘤标志物癌胚抗原(CEA)阳性率为30.0%；患者TNM分期绝大多数以Ⅲ-Ⅳ为主(95.2%)。结论 高原胃癌男性多见，中老年多见，胃窦部好发，早期诊断率低，恶性程度高，应根据高原地区胃癌临床发病特点因地制宜积极采取有效地综合防治措施。 |
| 关键词: 胃肿瘤 临床特征 高海拔 藏族 |
| DOI： |
| 投稿时间：2013-02-28修订日期：2013-06-19 |
| 基金项目:国家自然科学基金(81060206). |
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| Clinical features of gastric cancer in Tibet plateau region: an analysis of 237 cases |
| DAN Zeng1,LI Kang1*,LIU Xiao-bo1,ZE Yong-ge2,BIANBA Zha-xi2 |
(1. Department of Gastroenterology, People’s Hospital of Tibet Autonomous Region, Lhasa 850000, Tibet, China
2. Department of Oncology, People’s Hospital of Tibet Autonomous Region, Lhasa 850000, Tibet, China
*Corresponding author.) |
| Abstract: |
| Objective To investigate clinical features of 237 gastric cancer patients from plateau region in Tibet. Methods Clinical information of 237 patients with gastric cancer admitted to hospitals in the Tibet region was retrospectively analyzed. Clinical features including sex, age, clinical, endoscopic and histopathologic compositions were statistically compared. Results In all patients, the sex ratio of male to female was 3.2:1; 51.5% were aged from 40 to 59 years; 60.8% were peasants or cadres; 68.4% had tumors in gastric antrum; 82.3% had infiltrated type of gastric cancer; 81.0% presented with lowly-differentiated adenocarcinoma; the positive rate of CEA (carcino-embryonic antigen, as a tumor marker) was 30.0%; 95.2% had stages III to IV cancer evaluated based upon TNM criterion (tumor, node, metastasis). Conclusion In the Tibetan plateau, gastric cancer was commonly seen in gastric antrum of middle-aged or senior men. The severity of carcinoma was high. Effective and comprehensive measures should be actively adopted to prevent and treat gastric cancer in the plateau region according to local clinical features. |
| Key words: stomach neoplasms clinical features altitude zang nationality |
